Vascanox HP® is a nitric oxide supplement powered by Noxa24® that supports NO production, storage, and release for up to 24 hours with a single daily dose.*†

As we age, our body’s ability to produce nitric oxide naturally declines, which can affect circulation, energy levels, and overall vascular health. Vascanox HP was developed to address this challenge through a comprehensive, multi-pathway approach to nitric oxide support.*

How Does Vascanox HP Support Nitric Oxide Production?

Unlike typical nitric oxide supplements that rely on single precursors, Vascanox HP features Noxa24—a proprietary blend crafted to target multiple pathways for nitric oxide production, storage, and release.*

Key Benefits of Vascanox HP:*†

• Supports the eNOS (endothelial nitric oxide synthase) pathway
• Supports the nitrate-nitrite-NO pathway
• Supports NO production, storage, and release
• Supports nitric oxide production for up to 24 hours with one daily dose*†

Key Facts at a Glance

• What it is: Vascanox HP is a nitric oxide support supplement featuring Noxa24, a proprietary blend crafted to target multiple pathways for nitric oxide production, storage, and release.*
• Main ingredients: Noxa24, a patented extract blend of fermented black garlic, beetroot, and berries, combined with potassium nitrate.
• Key clinical outcomes: up to 24 hours of nitric oxide support with a single daily dose and supports blood pressure in the normal range*†
• Dosage: One daily dose, 2 capsules in the morning with food
• Timeline: Many people notice changes in energy, mental clarity or stamina within days to weeks.* 

Supporting healthy nitric oxide (NO) levels is key to maintaining optimal vascular health and overall circulation. Nitric oxide supports smooth blood flow, healthy vessel tone, and nutrient delivery throughout the body. 

Many supplements briefly boost NO levels, but few deliver support for up to 24 hours. Vascanox HP with Noxa24 from Calroy Health Sciences was developed to fill that gap. It is scientifically shown to support nitric oxide production for up to 24 hours from a single dose.*† 

For healthcare providers and health-activated individuals, Vascanox HP represents a science-backed, practitioner-trusted approach to consistent, multi-pathway nitric oxide support.

What is Nitric Oxide and Why is it Important?

Nitric oxide (NO) is a molecule naturally produced in the body that plays many roles in human health, but one of the most important is as a signal to help blood vessels to relax. This process, called vasodilation, helps maintain healthy blood flow and supports blood pressure in the normal range.* Beyond circulation, nitric oxide contributes to vascular resilience and healthy endothelial function, which is a key foundation of cardiovascular wellness.

Key physiological benefits of nitric oxide include:*

• Promoting vasodilation and circulation
• Supporting normal blood pressure
• Enhancing oxygen and nutrient delivery through the microcirculation

How is Nitric Oxide Produced in the Body?

The body generates nitric oxide primarily through two interconnected routes:

1. Endothelial Nitric Oxide Synthase (eNOS) Pathway: The pathway through which the body produces nitric oxide inside of the blood vessels.
2. Enterosalivary Nitrate-Nitrite-NO Pathway: Nitrates eaten in foods like leafy greens, celery, and beets are converted into nitric oxide through several pathways in the mouth and gut.

Limitations of Traditional Nitric Oxide Supplements

Typical nitric oxide supplements rely on single precursors such as dietary nitrites or L-arginine/L-citrulline. These can cause brief rises in NO but seldom sustain them. This one-pathway focus often falls short of maintaining a steady balance of NO production, storage, and release.

Common limitations include:

• Short duration of action (usually only a few hours)
• Limited pathway coverage
• Reduced efficacy with natural, age-related decline (nitric oxide naturally declines with age, mostly through the eNOS pathway)

Does Vascanox HP work?

Vascanox HP with Noxa24 was designed to address multiple pathways for next-generation nitric oxide optimization. In published human research, this supplement was shown to support nitric oxide levels for up to 24 hours with a single daily dose.*† The patented Noxa24 blend supports multiple pathways of nitric oxide production, storage, and release.*

Vascanox HP is among the first supplements shown to increase nitric oxide levels for up to 24 hours with a single daily dose.† In a published open-label study, salivary nitric oxide levels remained elevated throughout the day and night. 

Research also connects adequate nitric oxide with optimal circulation, endurance, and cognitive wellness, supporting whole-body vitality.*

Key studies include:

• Open-label study using salivary nitric oxide test strips.
• Characterization of the Role of Nitric Oxide and Its Clinical Applications
• Aging of the Nitric Oxide System: Are We as Old as Our NO?
• The nitrate–nitrite–nitric oxide pathway

Comparison of Noxa24 to Other Products

Key Ingredients and Their Roles in Nitric Oxide Pathways

Vascanox HP features Noxa24, Calroy’s patented extract blend of fermented black garlic, beetroot, and berries, combined with potassium nitrate. Together, these bioactives nourish the body’s nitric oxide pathways—supporting healthy circulation, vascular flexibility, and endurance throughout the day.*

Every bottle is produced under Calroy’s Total Quality System, with strict compliance to cGMP (current Good Manufacturing Practices) as defined by the FDA. Batch and test records are maintained throughout manufacturing to ensure the guaranteed quality of the final product.

Clinical Evidence and Practitioner Insights on Vascanox HP

Published human research on the full formulation shows that Vascanox HP raises salivary nitric oxide levels for up to 24 hours from a single daily dose.*† This duration distinguishes it from most short-acting formulations.

Healthcare practitioners often integrate Vascanox HP into comprehensive vascular health protocols, monitoring nitric oxide status via test strips, biomarkers and complementary endothelial glycocalyx-focused strategies. Clinicians report steady energy, improved endurance, and positive user feedback consistent with healthy nitric oxide.*

Practical Considerations and Safety for Healthcare Providers

If you have specific medical conditions or take prescriptions, we recommend speaking with your healthcare provider before adding any supplement to your routine. Vascanox HP is generally well tolerated. In most cases, it can be taken alongside other supplements or medications.

Nitric oxide test strips are a quick and easy way to assess whether or not an individual would benefit from nitric oxide support. 

Maximizing Nitric Oxide Support Through Lifestyle and Supplementation Integration

For the most effective nitric oxide support, work with a healthcare provider to create a vascular wellness plan. Regular exercise, a diet high in nitrate-containing vegetables and polyphenols, stress management, and consistent sleep all contribute to vascular health.

Best practices for comprehensive NO support:

1. Assess nitric oxide baseline (via NO test strips)
2. Prioritize at least 150 minutes of moderate activity per week, eating nitrate-dense food like leafy greens, and consistent sleep
3. Add Vascanox HP for nitric oxide support up to 24 hours*†
4. Reassess NO status periodically with practitioner guidance

Frequently Asked Questions

What is nitric oxide and why is it important for vascular health?

Nitric oxide is a molecule made in the body that relaxes blood vessels, improves blood flow, and supports healthy blood pressure in the normal range.* It also helps maintain resilient vascular function.*

How does endothelial glycocalyx health influence nitric oxide production?

The endothelial glycocalyx, a protective lining inside blood vessels, provides the environment for nitric oxide production. Shear stress from the blood pumping along this lining helps trigger healthy nitric oxide production on demand.*

How long can nitric oxide levels be supported with Vascanox HP?

In an open-label, published study, a single dose of Vascanox HP increased salivary nitric oxide levels for up to 24 hours.†

Are there safety considerations when combining nitric oxide supplements?

Yes. Combining nitric oxide supplements may increase additive circulatory effects; consult a healthcare provider before use or combining NO-supporting agents.

What lifestyle factors support effective nitric oxide production?

A diet high in leafy greens and beets, regular physical activity, sufficient sleep, and stress management all help support the body’s natural nitric oxide production.

How soon will I notice results with Vascanox HP?

Study participants demonstrated nitric oxide levels stayed elevated for up to 24 hours after a single dose.*† Many people notice changes in energy, mental clarity or stamina within days to weeks.* Salivary nitric oxide test strips can be helpful in assessing nitric oxide levels.

Are there any side effects or interactions with Vascanox HP?

If you have specific medical conditions or take prescriptions, we recommend speaking with your healthcare provider before adding any supplement to your routine. Vascanox HP is generally well tolerated. In most cases, it can be taken alongside other supplements or medications