Article Overview

This article defines nitric oxide, explains its role in human health, and outlines why it is important to optimize across time. It also explores three science-based ways to help support nitric oxide levels—through nutrition, exercise, and supplements—so you can promote circulatory support around the clock.*

Key Takeaways

• Nitric oxide production is important day and night, because it helps support a healthy vascular system that operates at all times.
• Regular movement, especially 150 minutes of moderate-intensity exercise weekly, stimulates nitric oxide production and trains blood vessels to maintain healthy tone around the clock.
• A nitrate-dense diet including beets, spinach, and arugula—spread across all meals including dinner—helps sustain nitric oxide levels throughout the day and night.
• Targeted supplementation with Vascanox HP provides nitric oxide support for up to 24 hours with a single daily dose, as shown in an open-label, published study.*†

Why is Nitric Oxide Important?

One of the most foundational aspects of human health is the vascular system. The vascular system is the network of about 60,000 blood vessels inside the body. It supports the flow of blood that delivers nutrients, oxygen, and hormones to their intended targets and cells.

Every single organ and cell in the body depends on healthy blood flow to function. 

A key component of healthy blood flow is nitric oxide. Nitric oxide is a molecule produced inside of the body. Among other roles, it helps support healthy blood flow by allowing blood vessels to relax. The body’s ability to both relax and contract vessels helps the blood move through the body to deliver oxygen and nutrients to the muscles, brain, heart, and all organs and cells as needed. That means less fatigue climbing stairs, steady focus at work, fast recovery after activity, and deep, more restorative rest.*

Healthy nitric oxide is critical for:

• Healthy blood pressure already in the normal range*
• Circulatory support for physical activity and recovery*
• Cognitive and sexual wellness through healthy vasodilation*

Quick definition: vasodilation refers to the ability of the blood vessels to relax, allowing nutrient-dense blood to reach its intended target.

What Is Nitric Oxide?

Discovered in Nobel Prize–winning research, nitric oxide has many varied and important roles in the body. One key area this article focuses on is nitric oxide. Nitric oxide is a molecule produced naturally in the body. It signals blood vessels to relax and open wide, supporting circulation, oxygen delivery, and cardiovascular wellness. But nitric oxide is also fleeting, lasting only milliseconds before it disappears. It must be produced continuously, on demand, to keep every muscle, organ, and brain cell supplied with the oxygen and nutrients they need.

The body constricts and relaxes the blood vessels to allow blood to move to target areas. The natural relaxation of blood vessels lowers blood pressure, and healthy nitric oxide assists in maintaining a normal blood pressure.*

How the Body Produces Nitric Oxide

The body generates nitric oxide through two main pathways. The first is the eNOS pathway, where the enzyme endothelial nitric oxide synthase (eNOS) in blood vessel walls converts L-arginine into nitric oxide. The second is the nitrate-nitrite-NO pathway, where dietary nitrates from foods like beets and leafy greens are converted by oral bacteria into nitrite, then further reduced to nitric oxide in the body.

Nitric oxide helps trigger the blood vessels to relax and allow blood to move to target areas. The natural relaxation of blood vessels supports blood pressure in the normal range.*

Is Nitric Oxide Important 24 Hours A Day?

Nitric oxide is important every hour of the day or night, because your body continuously transports nutrients and removes waste whether you are at work, on your daily walk, or even in your sleep.

During the day, your brain and organs rely on healthy blood flow to help you live your life. At night, it relies on healthy blood flow to help you sleep soundly, maintain healthy blood pressure in the normal range, clear toxins, consolidate memory, and restore balance to mood and energy systems.* Research shows that nitric oxide plays a vital role in this process by signaling blood vessels to relax so oxygen and nutrients can reach your brain.

Some people experience changes in blood pressure that only happen at night when they are sleeping. Supporting nitric oxide levels overnight helps maintain vascular flexibility and nocturnal blood pressure already within the normal range.*

The key takeaway: nitric oxide is essential every moment, not only during activity or stress but also during rest and sleep, when restoration and recovery occur.

For these reasons, healthy nitric oxide production is fundamental for overall health and wellness.

Calroy Health Sciences’ Approach to Nitric Oxide

Calroy advances human health by translating emerging scientific discoveries into breakthrough supplements that deliver real-world outcomes people and practitioners can trust.*

From circulation to cognition, heart health to joint mobility, Calroy develops clinically validated supplements with patented ingredients that restore and protect the body’s foundations.* True vitality begins deep inside your body’s systems.

Vascanox HP® with Noxa24® exemplifies this scientific commitment. Vascanox HP is among the first supplements shown to increase nitric oxide levels for up to 24 hours with a single daily dose, as measured by dietary nitric oxide test strips in a published, open-label study.*†

Learn more at calroy.com/product/vascanox-hp.

3 Tips for Healthy Nitric Oxide Throughout the Day and Night

Regular Movement to Support Vascular Health and Nitric Oxide

Exercise is one of the most reliable ways to support overall health, the vascular system, and healthy nitric oxide (NO) levels. The importance of regular movement cannot be understated when it comes to cardiovascular health. 

Movement directly stimulates your body to produce more NO. When you move, especially during aerobic or resistance training, blood flow increases. That pressure creates shear stress along the slippery inner lining of the blood vessel walls called the endothelial glycocalyx (EGX). This signals to the body to produce more nitric oxide. The result is improved vasodilation, meaning your blood vessels can relax to allow delivery of oxygen and nutrients to their intended targets.*

What’s especially powerful is that this effect doesn’t stop when the workout ends. Regular exercise helps “train” the endothelium, enhancing its ability to produce nitric oxide around the clock. Over time, this leads to better baseline vascular tone, improved circulation, and more efficient oxygen delivery, even at rest.

Nitrate-Dense Diet for Nitric Oxide Production

One foundation for sustained nitric oxide production is following healthy dietary patterns. A nitrate-rich eating plan centers on vegetables such as beets, spinach, arugula, and celery. These plants naturally supply dietary nitrate, which the body then naturally converts to nitric oxide. 

Because nitric oxide only lasts milliseconds in the body, it is important to sustain it throughout the day. A good way to do this is to eat nitrate-rich foods with every meal, including dinner. Spreading your nitrate intake throughout the day can help support nitric oxide availability throughout the day and night.

Vascanox HP with Noxa24 for Nitric Oxide Support for up to 24 Hours*†

Not all supplements sustain nitric oxide levels throughout the day. 

Vascanox HP® was purposefully developed to meet this need. In an open-label, published study, a single dose maintained elevated salivary nitric oxide for up to 24 hours.† This proprietary formulation acts through multiple pathways to support the body in production, storage, and delivery of nitric oxide.

†As measured by saliva NO test strips in an open label published study.

Vascanox HP supports:

• A healthy cardiovascular system*
• Blood pressure already within the normal range*
• Healthy, flexible circulation*

Frequently Asked Questions

How long do nitric oxide benefits typically last after supplementation or diet?

Dietary nitrate sources or supplements usually support nitric oxide for a few to several hours. Vascanox HP with Noxa24 provides nitric oxide support for up to 24 hours with a single dose, as shown in an open-label, published study.*†

How long do nitric oxide benefits typically last after taking Vascanox HP?

Vascanox HP with Noxa24 provides nitric oxide support for up to 24 hours with a single dose, as shown in an open-label, published study.*†

What are the best foods to support nitric oxide production?

Beets, spinach, arugula, and other leafy greens are excellent choices, especially alongside antioxidant-dense foods like dark chocolate and green tea.

Is nitric oxide important overnight?

Yes. Supporting nitric oxide overnight helps maintain healthy circulation, which translates to restorative rest, healthy removal of waste, and supporting blood pressure already in the normal range during sleep.* Your circulation works all the time, with no breaks. Nitric oxide is a big player in keeping that healthy.

Can lifestyle habits affect nitric oxide availability throughout the day?

Yes. Physical activity, nasal breathing, nitrate-dense foods, and targeted supplementation all reinforce nitric oxide production.*

Are there supplements that provide nitric oxide support during the day and night with a single dose?

Most nitric oxide support supplements provide support for a few hours. In an open-label, published study, Vascanox HP with Noxa24 was shown to support nitric oxide production for up to 24 hours with a single daily dose.*†

†As measured by saliva NO test strips in an open label published study.